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future opioids "if we could sniff or swallow something that would, for five or six hours each day, abolish our solitude as individuals, atone us with our fellows in a glowing exaltation of affection and make life in all its aspects seem not only worth living, but divinely beautiful and significant, and if this heavenly, world-transfiguring drug were of such a kind that we could wake up next morning with a clear head and an undamaged constitution - then, it seems to me, all our problems (and not merely the one small problem of discovering a novel pleasure) would be wholly solved and earth would become paradise." aldous huxley 1894 - 1963 the birth of a new generation a significant minority of the population only feel truly well on opioids. in effect, they self-medicate , taking responsibility for their own mental health in defiance of medical orthodoxy . it would indeed be extraordinary if - alone among the neurotransmitter systems of the brain - the endogenous opioid families were immune from dysfunction. enkephalins are critical to "basal hedonic tone" i.e. whether we naturally feel happy or sad. yet the therapeutic implications of a recognition that dysfunctional endogenous opioid systems underlie a spectrum of anxiety -disorders and depression are too radical - at present - for the medical establishment to contemplate. in consequence, the use of opioid -based pharmacotherapies for "psychological" pain is officially taboo. the unique efficacy of opioids in banishing mental distress is neglected. their unrivalled efficacy in treating "physical" nociceptive pain is grudgingly accepted. later this century and beyond, however, the development of highly selective, site-specific designer drugs and innovative gene-therapies may enhance our native opioid function and revolutionise mental health . therapeutic intervention targeted on the opioid pathways will potentially enrich the quality of life of even the nominally "well", not least because - by the more enlightened health standards of posterity - we may all be reckoned mentally ill. today, by contrast, immense energy is devoted by the authorities into persecuting " illicit " narcotic users. many drug-"abusers" feel well thanks only to the "non-therapeutic" use of opioids. they are stigmatised, pilloried and criminalised in a futile war against drugs . in the "inquisition against pleasure ", victims of medically-sanctioned human-rights abuses - e.g. the hundreds of thousands of drug "offenders" incarcerated in the amerikan gulag - are officially supposed to believe their malaise-ridden drug-naïve states were "normal", "natural" and mentally healthy. in the course of our ill-conceived drug war, vast resources are dissipated by the state-apparatus in an effort to choke off narcotic production and supply. when these efforts are temporarily successful, drug-deprivation makes the habitual opioid user feel ill; [s]he "cold-turkeys" with characteristic irritability, anhedonia, depression, sickness behaviour and sometimes raw physical pain . the ill-effects felt from involuntary deprivation of opioids are taken to demonstrate the likely ill-effects of legalised access , a paradox that might be thought laboured were its human costs not so tragic. when caught up in the criminal justice system, users may be pressured into taking opioid antagonists like naltrexone (trexan). such drugs can induce dysphoria and suicidal despair . at best, their use subtly diminishes the victim's capacity ever to feel well. meanwhile chinese military surgeons have developed (2003) a new treatment weapon against narcotic users: surgical destruction of the pleasure centres . western doctors are said to be following these procedures with interest, but are more likely to achieve their functional equivalent by non-surgical means. even where it is acknowledged that many opioid users have a pre-existing anxiety or depressive disorder in urgent need of relief, those so afflicted are fobbed off with often third-rate psychotropics instead. for a start, the monoamine hypothesis of depression - and the new classes of drug it has spawned ( ssri s, nari s, snri s, nassa s, rima s etc to complement the dirty old tricyclics and irreversible unselective maoi s) - is radically incomplete. a minority of people, admittedly, find such drugs effective. often taking a licensed antidepressant is better than nothing at all - perhaps in part because of their positive effects on endogenous opioid peptide release. yet even in the context of controlled clinical trials with relatively high dosage-regimens and artificially good rates of patient-compliance, it's rare for response-rates to reach more than 70%. rates of full remission of depressive symptoms are far lower, perhaps 25-30%. out "in the field", the picture is worse still. adverse side-effects are common. response may take weeks. withdrawal reactions can be unpleasant. a recognition of the crucial role of dopamine , and selective dopamine reuptake blockers , in sub-types of depressive mood-disorders might push response and remission rates higher. the mesolimbic dopamine system is critical to vitality, motivation , libido and a capacity to anticipate reward. dopaminergics can also act as analgesics . they can also reverse the apathetic sedation induced by some antidepressants and opioid agonists. yet the fda stymies the licensing of effective dopamine reuptake-blocking mood-brighteners at home; and applies pressure to deny access to them abroad. this is because of worries about their (sometimes) faster efficacy - and mild psychostimulant effect - raise the spectre of " abuse-potential "; and proscription, persecution and indiction are favoured over consumer education. for big brother knows best. more controversially, adding customised opioids , enkephalinase-inhibitors and kappa-antagonists to our therapeutic armamentarium may prove critical to boosting response- and remission-rates towards 100% in the decades ahead. crudely, whereas dopamine mediates " wanting ", mu opioid agonists mediate "liking". both systems can be fruitfully enhanced. depressive and dysthymic people often suffer from a dysfunctional opioid system and anhedonia - an incapacity to experience pleasure. sometimes orthodox "antidepressants" may even make them feel worse . yet controlled clinical trials of designer narcotics for refractory and/or melancholic depression, let alone their use by "normal" people with "ordinary" mood-disorders, are not imminent. opioid use isn't inherently life-shortening: for instance, chronic morphine administration extends longevity in vertebrate and invertebrate species alike. so what is to be done? even in the context of today's crude agents, would some of us be better off as legalised junkies? no, usually not, at least in contemporary society. self-medicating users with enough resources to maintain a regular supply may indeed find they can function as well as, or better than, their drug-naïve state. popular mythology aside, users don't seek to escalate dosage indefinitely: both humans and laboratory monkeys with unlimited access tend slowly to increase injection-frequency until eventually they self-administer a stable and subjectively optimal amount of the drug. most users take heroin, not primarily to stave off the abstinence syndrome, but because they find life on heroin better than their pain-ridden life without it. yet the existence of a typical heroin addict in prohibitionist society can still be exceedingly unpleasant at times. contemporary opioid drugs, natural and synthetic alike, are flawed. the problem is not the euphoric well-being they can induce - an ill-named "adverse side-effect" - but their tendency to induce a financially ruinous tolerance ; perhaps insidiously to dull the intellect ; trigger nausea ; slow digestive processes; and sometimes induce a parodoxical hyperalgesia . most seriously, when taken in acute excess, today's opioids can cause respiratory depression . this is a consequen

URL analysis for opioids.com

https://www.opioids.com/offshorepharmacy/index.html
https://www.opioids.com/kappa/dopamine-reg.html
https://www.opioids.com/resource/index.html
https://www.opioids.com/opiates.html
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https://www.opioids.com/stress/dynorphin.html
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https://www.opioids.com/antidepressant/depression-subtypes.html
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https://www.opioids.com/dequincey/index.html
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https://www.opioids.com/receptors/index.html
https://www.opioids.com/legal/index.html
https://www.opioids.com/offshorepharmacy/pain-medication.html
https://www.opioids.com/tramadol/tramadol.html
codeine.co.uk

Whois Information

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Domain Name: OPIOIDS.COM
Registry Domain ID: 3182367_DOMAIN_COM-VRSN
Registrar WHOIS Server: whois.tucows.com
Registrar URL: http://www.tucowsdomains.com
Updated Date: 2018-02-26T22:57:57Z
Creation Date: 1998-10-17T04:00:00Z
Registry Expiry Date: 2025-10-16T04:00:00Z
Registrar: Tucows Domains Inc.
Registrar IANA ID: 69
Registrar Abuse Contact Email:
Registrar Abuse Contact Phone:
Domain Status: clientTransferProhibited https://icann.org/epp#clientTransferProhibited
Domain Status: clientUpdateProhibited https://icann.org/epp#clientUpdateProhibited
Name Server: NS3.BLTC.NET
Name Server: NS4.BLTC.NET
DNSSEC: unsigned
URL of the ICANN Whois Inaccuracy Complaint Form: https://www.icann.org/wicf/
>>> Last update of whois database: 2018-11-10T19:05:11Z <<<

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  REGISTRAR Tucows Domains Inc.

SERVERS

  SERVER com.whois-servers.net

  ARGS domain =opioids.com

  PORT 43

  TYPE domain

DOMAIN

  NAME opioids.com

  CHANGED 2018-02-26

  CREATED 1998-10-17

STATUS
clientTransferProhibited https://icann.org/epp#clientTransferProhibited
clientUpdateProhibited https://icann.org/epp#clientUpdateProhibited

NSERVER

  NS3.BLTC.NET 52.44.246.5

  NS4.BLTC.NET 52.44.246.5

  REGISTERED yes

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